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Bench Scientist III
Ref No.: 17-06988
Location: La Jolla, California
Start Date / End Date: 01/02/2018 to 01/01/2019
Job Description: The individual in this position is responsible for the discovery, development, validation, and implementation of pharmacodynamic and mechanistic biomarker assays in support of clinical development of oncology agents.


• Client, develop, optimize, and implement pharmacodynamic (PD) and proof-of-mechanism (PoM) biomarker assays to enable and support clinical trial PoM decisions.
• Develop, validate and execute biomarker assays to support Phase 1/2 clinical studies
• Design and execute preclinical studies in relevant models and/or human samples to enable validation of clinically translatable biomarker approaches.
• Explore Client concepts and innovative technologies to expand the group’s biomarker discovery capabilities.
• Meet appropriate regulatory guidelines for biomarker assessment of clinical tissue specimens
• Ensure all tasks and responsibilities are carried out according to scientific and ethical standards.
• Interface with colleagues in development teams and provide input in sample logistics in clinical protocols.

• Knowledge of molecular biology and laboratory safety procedures for handling hazardous chemicals and biosafety level 2 biohazard materials
• Knowledge of standard molecular biology laboratory equipment
• Excellent written and verbal communication skills
• Ability to work independently
• Ability to interface with clinical research teams
• Proficiency with standard office software (Microsoft Office, Adobe Acrobat)

• BS/MS. in a biological science with > 5 years’ experience in assay development/validation with a focus on cancer biology and biomarkers
• Multiple years of experience working on drug discovery projects in an industrial team setting.
• Experience in current molecular biology techniques, including RT-PCR, western blotting, and gene expression profiling.
• Experience working with human tissue biospecimens, including various types of tumor, blood, and skin samples.
• Experience with next generation DNA/RNA sequencing (NGS), NanoString/HTG analysis of mRNA, or analysis of circulating, cell-free tumor DNA/RNA strongly preferred.
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