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Upstream Process Development Associate
Ref No.: 20-00201
Category: Biotechnology
Location: Pearl River, New York
As an Upstream Process Development Associate, the incumbent will assist in the planning and execution of mammalian cell culture experiments required to develop upstream processes for the production of viral vaccine candidates. The incumbent will work with the development team to design and optimize cell culture media and process parameters to enhance growth, product yield and quality. The upstream development group will work closely with the downstream process development group in evaluating optimal conditions for the purification of the viral vaccine candidates.


Responsibilities:
  • Develop robust, high-yield and scalable mammalian cell culture processes for the production ofviral vaccine candidates
  • Ability to plan and execute cell culture activities with limited guidance.
  • Demonstrate the ability to operate, maintain relevant instruments, and resolve technical problems related to instruments
  • Execute analytical characterization methods for both upstream and downstream samples
  • Analyze and document experimental data generated
  • Participate in technology transfer of processes to contract manufacturing organization (CMO) for the cGMP manufacture of the viral vaccine vectors
  • Write detailed experimental protocols/SOPs, reviews and reports data appropriately, contributes to technical reports. Summarize results in written reports and oral presentations
  • Ability to foster a collaborative work environment with internal and external partners

Qualifications
  • PhD in biotechnology, cell biology, biochemistry or related biological sciences, with minimal 2+ years or MS with minimal 6+ years of relevant industrial experience
  • The position requires excellent aseptic techniques and experience in culturing mammalian cell lines
  • Familiarization of stirred reactor vessels and/or fixed-bed reactors
  • Experience in SDS-PAGE electrophoresis, Western blotting, DNA sequencing, viral titrations, UV/VIS spectroscopy, immunoplaque staining
  • Basic knowledge of GMP/GLP regulations in cGMP/cGLP manufacturing environment preferred
  • Good problem-solving and critical thinking skills
  • Effective communication skills
  • Good MS Excel and Word skills
  • Excellent organization skills
  • Ability to execute tasks and studies based on the deliverable timeline
  • Ability to function in a rapidly changing environment