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Ref No.: 18-12082
Location: Spring House, Pennsylvania
Start Date / End Date: 10/08/2018 to 10/04/2019
Associate Scientist II, Hematological Malignancies Discovery Biology

The candidate will join the Hematological Malignancies disease area discovery biology team to assist with target validation and evaluation of small and large molecule therapies for the treatment of blood cancers. S/he will work as part of a team driving research programs across the different stages of pre-clinical drug discovery. His/her responsibilities include the design, execution and interpretation of studies for the development of Client therapeutic agents. The scientist will collaborate with colleagues across multiple departments and communicate scientific results to multidisciplinary teams.

The Scientist will:

•Work within the Hematological Malignancies drug discovery team to execute in vitro and ex vivo experiments
•Have a deep understanding of both immunology and oncology
•Develop cell- based assays to evaluate molecules regulating apoptosis
•Perform cell-based assays including the following: FACS analysis, ELISA, MSD, immune cell isolation from whole blood or tissues, cell culture, western blotting, transfection and cloning of stable cell lines, and other functional assays, etc.
•Analyze complex data sets, maintain electronic notebook records, and present data in professional 'publication ready' format at internal meetings
•Work independently with minimal supervision and manage multiple projects simultaneously
•Possess intrapersonal skills to collaborate with stakeholders from all relevant functional areas of drug discovery
•Keep up-to-date with the literature related to his/her field
•Demonstrate clear and professional verbal and written communication


•M.S./M.A. in life sciences with 2+ years of experience or a B.S./B.A. with 4+ years of experience is required
•Experience with flow cytometry techniques, flow cytometry analysis, and multicolor flow cytometry is required
•Experience in development of cell-based assays, working with primary immune and bone marrow cells, and ex- vivo analyses is required
•Basic immune cell purification techniques and immunological phenotyping procedures, as well as processing primary human and/or rodent tissues and blood is required
•Basic aseptic cell culture technique, such as maintaining cell lines and primary cells, cell baning, etc. is required
•Strong organizational skills including the ability to manage several projects simultaneously and experience working under fixed timelines
•Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is preferred
•Detail-oriented, with excellent record-keeping skills
•Excellent oral and written communication skills is required
•Experience with MS Office suites required
•Ability to effectively present scientific data and concepts
•Up to 10% travel may be required