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Research Associate, Method Innovation and Characterization
Ref No.: 18-08675
Location: Cambridge, Massachusetts
Start Date: 07/17/2018
The Role:
This position as a research associate, Method Innovation and Characterization in Drug Product Analytical Development (DP-AD) group will be responsible for optimizing and prequalification of physico-chemical characterization methods of mRNA formulations in a dynamic and highly interdisciplinary environment. The candidate will also be supporting Client process development and prototype stability with both established and Client analytical techniques. He\she will be working closely with a senior member of the group so effective team work is important for this role. In addition, the candidate should be able to contribute characterization source documentation to support technical reports and regulatory submissions.

Here's What You'll Do:
  • Optimize and prequalify Client analytical techniques to characterize lipid nano-particles to support process development and formulation design.
  • Collaborate with internal groups in chemistry, formulations, delivery, drug substance analytical and In-vitro Biology.
  • Communicate research and development findings internally in a timely fashion.
QUALIFICATIONS
  • Bachelors with 1-2 years of experience.
  • Masters with 0-1 years of experience
  • Experience in nucleic acid drug development (DNA, RNA, oligonucleotides)
  • Familiar with common analytical techniques such as UV, Fluorescence, HPLC, LCMS, CE, GC, NMR, KF, IR, etc.
  • Familiar with analytical techniques for determining heterogeneity of nanoparticles including SEC/FFF-MALS and other HPLC separation techniques such as IEX, RP, HIC etc.
  • Familiar/Experience with Encapsulation techniques using Fluorescence or HPLC separation principles.
  • Experience with various biophysical and light scattering techniques (DLS, NTA, Coulter Counter, etc.)
  • Effective communication skills and the ability to write detailed technical reports
  • Strong interpersonal skills with an eagerness to support colleagues in Research, AD, CMC, Manufacturing and Process Development