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Scientist IV
Ref No.: 18-07548
Location: San Diego, California
Start Date / End Date: 07/01/2018 to 02/01/2019
Overview:
The development of biotherapeutics to treat neurological diseases has been hampered in significant part due to the intrinsically poor permeability of the blood-brain barrier for large proteins. One commonly exploited path for increasing brain penetration of biotherapeutics is receptor-mediated transcytosis. While current receptor-mediated transcytosis platforms have succeeded in increasing the brain delivery of biotherapeutics, several deficiencies remain. Addressing these deficiencies will be the focus of this project. Within this context, the post-doctoral fellow will have latitude to explore a variety of factors aimed at improving efficiency of transcytosis across the blood-brain barrier.

As a member of the multi-disciplinary blood-brain barrier team, the scientist will learn to leverage their knowledge of blood-brain barrier biology into the design of biotherapeutics. The candidate’s involvment in this highly matrixed organization will provide the opportunity to explore the biotherapeutics discovery process and mAb engineering approaches, while working closely with discovery teams aimed at developing compounds to treat Alzheimer’s Disease.

Qualification:
Suitable candidates will have a PhD in cell biology, neuroscience or a related field with an additional 0-2 years of experience in relevant research. The ideal candidate will have a strong background in blood-brain barrier biology, invitro blood-brain barrier models and endosomal trafficking.
Independent, multitasking, multi-displinary capabilites with strong communication skills (written and verbal) are also required.

Skill Sets:
-Broad knowledge of cell biology, endosomal trafficking and blood-brain barrier biology.
-Strong expertise working with a wide variety of cell types and cell culture, including brain endothelial cells and iPSCs.
-Confocal microscopy.
-General experience with molecular biology, protein expression and purification, in vitro biochemical assays, ELISA, MSD, and cell-based functional assays.