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Sr. Research Associate
Ref No.: 18-07406
Location: Cambridge, Massachusetts
Position Type:Contract
Start Date: 06/19/2018
The Role:
Client is seeking a highly skilled, talented and motivated in vitro analyst for a position based at their Cambridge, MA site. The individual will participate in the development and performance of cellular and biochemical potency assays to support advancement of client's mRNA clinical development candidates.
Here's What You'll Do:
  • Development and performance of in vitro assays (ELISA, FACS, PCR, Western blotting, luminescence, functional activity) using cultured and primary mammalian cells to support product development
  • Transfer of potency assays to CRO/QC laboratory for qualification and validation, for release and stability testing under GMP
  • Standard mammalian cell culture support including maintaining and plating of cell lines
  • General laboratory assistance including lab equipment maintenance, preparation of reagents, and the ordering and receiving of lab supplies
  • Closely collaborate with members of the In Vitro Biology, Technical Development and Quality Control teams, and broadly with R&D departments throughout the company
  • Accountable for experiment design, success and results delivery
  • Record and communicate findings
  • Presentation of results at internal meetings
Here's What You'll Bring to the Table:
  • BS with 2-5 years of industry experience, or MS with 0-2 years of industry experience (Cell Biology, Biochemistry, Molecular Biology, or related science), developing and performing cellular and biochemical assays, preferably in a GMP environment
  • Hands on experience with mammalian cell culture and the utilization of cell-based assays to examine the expression and activity of a variety of protein targets
  • Significant experience in ELISA assay development and performance
  • Excellent interpersonal, organizational, and collaborative skills, attentive to detail, and the ability to work independently and effectively in a highly dynamic environment
  • Preferred; Familiarity with the regulatory landscape and government agency guidance for potency assay development, qualification and validation
  • Preferred: Familiarity with nucleic acid therapeutic characterization
  • Preferred; Ability to multi-task to meet aggressive timelines and development goals