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Research Associate Scientist
Ref No.: 18-08445
Location: Waltham, Massachusetts
Start Date / End Date: 07/30/2018 to 01/25/2019
Hematology research at Client, a Sanofi Company, is looking for an enthusiastic and self-motivated temporary research associate scientist to perform basic research towards therapeutic development hematological diseases.

The candidate will design, execute and troubleshoot experiments and will be responsible for analyzing and interpreting results. Research work will be focused mainly on in vitro assays with cultured cell lines and primary cells obtained from human donors. The associate is also expected to work with in vivo mouse models which involves dosing of experimental compounds and harvesting blood and other tissues for ex vivo assays. The prospective candidate should be skilled in basic and advanced techniques in molecular and cell biology and ideally possess hands on experience in working with laboratory animals. Specific responsibilities include:
1. Culture of primary CD34+ stem cells through differentiation and characterization
2. Screening and testing experimental small molecule compounds in both primary cells and cultured cell lines for various end points
3. Experience with flow cytometry, molecular biological techniques such as mRNA isolation and real time PCR, protein assays including ELISA and western blotting
4. In vivo research involving dosing of mouse models with experimental compounds routinely and harvesting of tissues and samples.
Qualifications
A minimum of 3-5 years experience in the Pharmaceutical Industry, working in a research laboratory
• B.S. or M.S. in Molecular Biology, Cell Biology or Immunology with 3 years of relevant experience
• Working hands on experience in common laboratory in vitro techniques such as cell culture, ELISA, and molecular biology
• In vivo work experience in rodent handling and drug delivery (IV, IP, SC. IM, Oral)
• Extensive experience in mouse tissue dissection/collection and processing, and blood collection and subsequent laboratory work in bioanalysis of collected samples using FACS, real time PCR, and other methods
• Excellent oral and written communication skills
• Ability to work as part of a cross-functional team is required.
• Good organizational, interpersonal and communication skills (oral and writing) are desired.

Required / Desired Skills
Skill
Required / Desired
Amount
of Experience
Experience with flow cytometry, molecular biological techniques such as mRNA isolation
Required
3
Years
Experience with Screening and testing experimental small molecule compounds in both primary cells and cultured cell lines for various end points
Required
3
Years
Vivo research involving dosing of mouse models
Required
3
Years
Pharmaceutical Industry
Required
3
Years

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