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Scientist-I
Ref No.: 18-21237
Location: Spring House, Pennsylvania
Job Title: Scientist
Location: Welsh And Mckean Road, Spring House, PA 19477
Duration: 12 Months
 
Manager states that the below are the important points
 
Demonstrated knowledge of the current Molecular Biology techniques in the realm of Antibody/Protein Engineering, hands-on experience with high-throughput construct design, restriction-free and restriction-based cloning is required
 
Description:
 
In this laboratory-based position, the Associate Scientist will join the Antibody Engineering/Bispecifics group to perform hands-on Antibody/Protein Engineering activities to support discovery and development of monoclonal antibodies, bispecifics and CAR-T.
 
  • The position offers an exciting opportunity to engage in the discovery and molecular engineering of Biotherapeutics for unmet medical needs. You will be an integral member of the Antibody Engineering group and the Associate Scientist role would include:
  • Molecular biology tasks such as PCR-based cloning, construct design, site-directed mutagenesis, expression vector engineering etc.,
  • Binding and/or cell-based assays development and screening for antibody sequence optimized variants
  • Design, selection and optimization of scFv/Fab from antibodies for multi-specific formatting and as modules for CAR-T
  • Independently presents/defends scientific findings in cross-functional project teams/initiatives, drafts protocols, SOPs, technical reports etc.
 
Qualifications
  • M.S in molecular biology, biochemistry, biophysics, immunology or a related discipline with a minimum of two years of experience OR a BS degree in molecular biology, biochemistry, immunology, or related discipline with at least five years of experience is required (preferably in industry setting)
  • Demonstrated knowledge of the current Molecular Biology techniques in the realm of Antibody/Protein Engineering, hands-on experience with high-throughput construct design, restriction-free and restriction-based cloning is required
  • Clinical/Preclinical discovery of antibody based biotherapeutics in an industrial setting is preferred
  • Hands on experience with bispecific and/or CAR-T scaffold design, engineering and profiling is preferred
  • Hands-on experience in HTP-based binding assays (such as ELISA, SPR, MSD) and/or cell-based (Intellicyt/iQue) for screening antibody variants is preferred
  • Hands on experience in Phage or Yeast Display technology for discovery and/or optimization is preferred