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Scientist - Biotherapeutics
Ref No.: 18-11746
Location: Spring House, Pennsylvania
Job Title: Scientist - Biotherapeutics
Location: Welsh & Mckean Roads, Spring House, PA 19477
Duration: 12 Months

The position offers an exciting opportunity to engage in the discovery and molecular engineering of Biotherapeutics for unmet medical needs. You will be an integral member of the Antibody V gene cloning group and the Scientist role would include:
  • Molecular biology tasks such as PCR-based cloning, construct design, RNA purification, RT-PCR, expression vector engineering etc.,
  • High Throughput V gene recovery from Hybridomas or single B cell(Client) platform
  • Computational expertise in DNA sequence analysis and in silico cloning
  • •Independently presents/defends scientific findings in cross-functional project teams/initiatives, drafts protocols, SOPs, technical reports etc.
  • •M.S in molecular biology, biochemistry, biophysics, immunology or a related discipline with a minimum of two years of experience OR a BS degree in molecular biology, biochemistry, immunology, or related discipline with at least five years of experience is required (preferably in industry setting)
    • Demonstrated knowledge of the current Molecular Biology techniques in the realm of Antibody/Protein Engineering, hands-on experience with high-throughput construct design, restriction-free and restriction-based cloning is required
    • Clinical/Preclinical discovery of antibody based biotherapeutics in an industrial setting is preferred
    • Hands on experience with bispecific and/or CAR-T scaffold design, engineering and profiling is preferred
    • Hands-on experience in HTP-based binding assays (such as ELISA, SPR, MSD) and/or cell-based (Intellicyt/iQue) for screening antibody variants is preferred
    • Hands on experience in Phage or Yeast Display technology for discovery and/or optimization is preferred