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Associate Scientist III - R&D – Biotherapeutics
Ref No.: 18-11674
Location: Redwood City, California
Job Title: Associate Scientist III - R&D – Biotherapeutics
Location: 1400 & 1500 Seaport Blvd. Building H, Redwood City, CA 94063
Duration: 9 Months

Attach questions with resume!

Screening Questions for potential Bioassay Development candidates.
  1. What does ELISA stand for? Please describe the steps to perform an indirect sandwich ELISA. What are the advantages of this type of ELISA compared to other ELISA formats? What are the disadvantages?
  1. Do you need to include controls in your indirect sandwich ELISA? If controls are needed, what controls will you have and why did you choose these controls?
  1. If your assay plate has no ELISA signal, please describe one follow-up experiment that you will run to assess the potential causes. Conversely, if your assay plate has too high of a signal, what experiment will you run to help determine the cause?
  • Associate Scientist in the Bioassay Development group. In this lab-based position you will primarily perform binding potency assays and cell-based functional assays to support the development of Immuno-Oncology (I-O) therapeutic proteins.
  • This role will support analytical testing, method qualification, method transfer to Quality Control labs, and CMC drug development activities.
  • Responsibilities will include performing, improving, and troubleshooting assays, monitoring and testing of critical reagents, documentation of work in technical reports to support regulatory filings, and presenting work at internal meetings.

The Bioassay Development group exists within the CMC (Chemistry, Manufacturing, and Controls) department. In this department you will be exposed to many related areas of drug development, such as cell line/culture development, protein purification, pharmaceutical development/formulation, and analytical sciences.

Preferred Qualifications:
  • A background in cell/molecular biology and bioassays is preferred.
  • Experience performing binding potency ELISAs and cell-based assays is required.
  • Bioassay development and qualification/validation experience in a process development or QC environment is a plus.
  • The ideal candidate will have a minimum of a 4-year degree in biology or a related life science major, plus 4-6 years of experience in a laboratory environment.
  • It is essential that the candidate have good verbal and written communication skills, in addition to demonstrating excellent interpersonal skills, as the candidate will be required to work collaboratively and to efficiently and effectively multi-task in a fast-paced team environment.