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R&D Researcher/Oligonucleotide Synthesis Chemist
Ref No.: 17-25125
Location: Boulder, Colorado
Job Title: R&D Researcher/ Oligonucleotide Synthesis Chemist
Location: 5555 Airport Blvd, Boulder, CO 80301
Duration: 12 – 18 months

Job Description:
  • Client is seeking a research associate to work with a team developing and scaling Client chemistries for RNA synthesis.
  • Key responsibilities will include the preparation and purification of synthetic RNA and chemically modified synthetic RNA using automated solid-phase synthesis techniques
  • You will be pushing RNA synthesis state of the art using Client's proprietary TC-RNA chemistry, and will be responsible for ordering, maintaining, and monitoring an inventory of chemical reagents, as well as maintenance and monitoring of the hardware components used for the synthesis, purification and analysis of the RNA products
  • You will be expected to help develop and optimize synthetic protocols and purification protocols, and be able to organize the data generated into clear and easy to read reports

  • BS/BA or MS/MA or PhD in Chemistry or Biochemistry, or equivalent.
  • Research experience in support of synthetic organic chemistry research or development projects.
  • 2+ years of experience in solid-phase oligonucleotide synthesis, using and trouble-shooting automated solid-phase synthesizers and optimizing synthetic protocols and reaction schemas.
  • 2+ years of experience in the evaluation, analysis, characterization, purification, and optimization of purification protocols of oligonucleotides (RNA and DNA) via HPLC.
  • Hands-on experience manipulating and synthesizing RNA in an R&D environment and practiced in anhydrous and RNAse-free lab techniques.
  • Practiced in the development and bottling of buffers and reagents, as well as the management of laboratory chemicals and raw materials inventories.
  • Ability to work independently and to execute and troubleshoot new methods.
  • Familiarity with a broad range of affinity chromatography techniques.
  • Experience with NMR and Mass Spectrometry.
  • Excellent time management, record keeping, teamwork and communication skills.
  • Computer literacy including proficiency with Word and Excel.